Immunology Research – Biomarkers and Immunoassays
Normally the immune system is an organized, complex network of biological structures and processes that protect against disease. For example, cytokines and chemokines, proteins of the inflammation pathway, mediate interactions between cells directly, regulating target immune cell responses. These responses result in inflammation, which is the immune system`s method of eradicating foreign antigens and beginning the healing process. Consequently, the inflammation pathway plays a key protective role in immunity.
Inflammation and Autoimmune Disease
Normally the immune system can distinguish pathogens and tumor cells from the organism's own healthy cells and tissues. However, immune responses in which cytotoxic cells are directed against self antigens occur in autoimmune diseases. In such disorders as rheumatoid arthritis, Crohn's disease and psoriasis, prolonged inflammation results in tissue destruction. Other aberrant immune disorders include allergic reactions, chronic inflammatory disease, and cancer.
Multiplexed Detection of Inflammation Biomarkers
Based on the Luminex xMAP platform, Millipore offers the broadest selection of inflammation and immunology biomarkers available in a single panel for a variety of human and animal models. MILLIPLEX MAP multiplex panels enable you to investigate the modulation and expression of dozens of analytes simultaneously, giving you the advantage of speed and sensitivity, which can dramatically improve productivity.
Research Poster Spotlight
Biological Evaluation of MILLIPLEX® MAP Human and Mouse Th17 Panels
T-cell differentiation and their cytokine secretion regulate immune response, chronic inflammation, autoimmune diseases and cancer. Enhance your immunology research with our Mouse Th17 magnetic bead panel by selecting up to 25 cytokines expressed by Th1, Th2 and Th17 cells.
In our latest study, we used the recently developed MILLIPLEX® MAP Human and Mouse Th17 panels to analyze the cytokine secretion in human and mouse PBMCs stimulated with lipopolysaccharide (LPS), concanavalin A (Con A) or Phytohemagglutinin (PHA). We also examined the effect of Adiponectin pretreatment on the LPS- or Con A-induced PBMC response.
