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ProductsBack/3-Bromopyruvic acid [1113-59-3]
Chemical Structure
Chemical Structure
Chemical Structure

3-Bromopyruvic acid [1113-59-3]

Research Use Only
AG-CR1-3682
AdipoGen Life Sciences
Estimated Purity>98%
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Product group Chemicals
Molecular Weight167
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    3-Bromopyruvic acid [1113-59-3]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C3H3BrO3
  • Molecular Weight
    167
  • Scientific Description
    Cell permeable pyruvic acid derivative. Hexokinase II (HK2) inhibitor. Useful agent for immunometabolism research. Antitumor agent. Inhibits the rate limiting step of glycolysis and effectively suppress tumor survival in vitro and in vivo. Displays potent cytotoxic activity against cancer cells with mitochondrial respiratory defects and cells in hypoxic environment. Antifungal agent (anticryptococcal). Also used as affinity label for cysteine residues and cross-linker between nucleic acids and proteins. - Chemical. CAS: 1113-59-3. Formula: C3H3BrO3. MW: 167. Synthetic. Cell-permeable pyruvic acid derivative. Hexokinase II (HK2) inhibitor. Useful agent for immunometabolism research. Antitumor agent. Inhibits the rate limiting step of glycolysis and effectively suppress tumor survival in vitro and in vivo. Displays potent cytotoxic activity against cancer cells with mitochondrial respiratory defects and cells in hypoxic environment. Antifungal agent (anticryptococcal). Also used as affinity label for cysteine residues and cross-linker between nucleic acids and proteins.
  • SMILES
    O=C(CBr)C(O)=O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate: Z. Chen, et al.; Biochim. Biophys. Acta. 1787, 553 (2009)
  • Specificity of the anti-glycolytic activity of 3-bromopyruvate confirmed by FDG uptake in a rat model of breast cancer: M. Buijs, et al.; Invest. New Drugs 27, 120 (2009)
  • 3-Bromopyruvate: a novel antifungal agent against the human pathogen Cryptococcus neoformans: M. Dyląg, et al.; BBRC 434, 322 (2013)
  • 3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings: L. Gong, et al.; Anticancer Agents Med. Chem. 14, 771 (2014)
  • A guide to immunometabolism for immunologists: L.A. O'Neill, et al.; Nat. Rev. Immunol. 16, 553 (2016)