Anti-Human Osteopontin (10A16) Mouse IgG MoAb

Catalog number: 10011-200uG
Brand: IBL Japan
Packing: 200 ug
Price: On Request
Expected delivery time: 10 days
Quantity:

Product specifications for - Anti-Human Osteopontin (10A16) Mouse IgG MoAb

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot, ImmunoHistoChemistry
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Source: Mouse-Mouse hybridoma
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Form supplied: Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Scientific information: 
Scientific info: Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other fluids and tissues including milk, urine, activated T cells, smooth muscle cells, kidney and some tumor cells. OPN contains an Arg-Gly-Asp (RGD) amino acid sequence. This motif is present in fibronectin, vitronectin and a variety of other extra-cellular proteins that bind members of the integrin family of cell surface receptors such as alphavbeta3. OPN was also identified as a ligand for CD44, which levels correlate with aggressiveness of lymphoid tumors and invasiveness of bladder carcinoma. Its interaction does not require RGD motif of OPN. In OPN knockout mice, it has been reported that a significantly decreased level of debridement was shown. Although the distribution and expression pattern of OPN in the human body have suggested the multiple function of OPN, its function under different situations remain obscure. And it is reported the N-terminal OPN fragment cleaved by thrombin (OPN N-Half) binds to alpha4 or alpha9 integrin, and the relation with many inflammatory disease is suggested.
Clone ID: 10A16
Additional information: 
Synonyms: 10011; IBL Japan; Osteopontin 10A16 Human Antibody