Anti-Human RGMa (410-10) Mouse IgG MoAb

Catalog number: 10377-100uG
Brand: IBL Japan
Packing: 100 ug
Other sizes: Other sizes available
Price: On Request
Expected delivery time: 10 days

Product specifications for - Anti-Human RGMa (410-10) Mouse IgG MoAb

Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot, ImmunoPrecipitation, FCM
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2b
Source: Mouse-Mouse hybridoma (X63 - Ag 8.653 x BALB/c mouse spleen cells, supernatant)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Form supplied: Lyophilized product from 1 % BSA in PBS containing 0.05 % NaN3
Scientific information: 
Scientific info: RGMa (Repulsive Guidance Molecule a) is a GIP-anchored protein, about 33 kDa, and it is implicated in axonal guidance and neural tube closure of embryonic retina. It has reported as a potent inhibitor of axonal regeneration in the adult central nervous system (CNS). It is speculated that RGMa inhibits neurite outgrowth by activating the RhoA-Rho kinase signaling pathway in vitro. While, it has reported that, in a rat SCI (spinal cord injury) model, neurite outgrowth is enhanced by administration of anti-RGMa antibody to lesion site, resulting they are improved in mortor functional recovery. Thus function analysis of RGMa is attracting attention in a research field of axonal regeneration of CNS. This antibody detects human RGMa and can be used for western blotting, immuno-precipitation and FACS analysis.
Clone ID: 410-10
Additional information: 
Synonyms: 10377; IBL Japan; RGMa 410-10 Human Antibody