Anti-HumanAmyloidbeta (11-28) (12B2) Mouse IgG MoAb

Catalog number: 10027-50uG
Brand: IBL Japan
Packing: 50 ug
Other sizes: Other sizes available
Price: On Request
Expected delivery time: 10 days

Product specifications for - Anti-HumanAmyloidbeta (11-28) (12B2) Mouse IgG MoAb

Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot, ImmunoPrecipitation, ImmunoHistoChemistry
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Source: Mouse-Mouse hybridoma
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Form supplied: Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3
Scientific information: 
Scientific info: Alzheimer's disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid (Abeta) peptide, a 40 to 43 amino acid peptide cleaved from amyloid precursor protein by beta-secretase and gamma-secretase. Increased release of Abeta42 or Abeta43, both of which exibit a greater tendency to aggregate than Abeta40, occurs in individuals expressing certain genetic mutations, ApoE alleles or may involve other undiscovered factors. Many researchers theorize that it is this increased release of Abeta42/Abeta43 which leads to the abnormal deposition of Abeta and the associated neurotoxicity in the brains of affected individuals. It is also reported that a distinct Abetapeptide, AbetaN3pE, is deposited in senile plaques in a dominant and differential manner as compared with the standard Abetapeptide.
Clone ID: 12B2
Additional information: 
Synonyms: 10027; IBL Japan; Amyloid Beta Aβ (11-28) 12B2 Human Antibody