BRCC3 Antibody

Cusabio

BRCC3 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Metalloprotease that specifically cleaves \\\Lys-63\\\-linked polyubiquitin chains. Does not have activity toward \\\Lys-48\\\-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes \\\Lys-63\\\-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes \\\Lys-63\\\-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves \\\Lys-63\\\-linked ubiquitin in various substrates. Mediates the specific \\\Lys-63\\\-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.

Human

-20°C or -80°C

12352203