FOS Antibody

Cusabio

FOS Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. Qi Mei, Am J Physiol Endocrinol Metab, Oct 2001; 281: E655 - E664. Jennifer R. Brown, Mol. Cell. Biol., Sep 1998; 18: 5609 - 5619. T K Kerppola, Mol. Cell. Biol., Jun 1993; 13: 3782 - 3791. L J Ransone, Genes & Dev., Jun 1989; 3: 770 - 781.

Human, Mouse, Rat

-20°C or -80°C

12352203