LIG4 Antibody

Cusabio

LIG4 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Wei Y.-F., Mol. Cell. Biol. 15:3206-3216(1995). Dunham A., Nature 428:522-528(2004). Robins P., J. Biol. Chem. 271:24257-24261(1996).

Human

-20°C or -80°C

12352203