Bio-Connect

LMP2 Antibody, HRP conjugated

Research Use Only
CSB-PA321086HB01EFA
Cusabio
ApplicationsELISA
Product group Antibodies
ReactivityVirus
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Cusabio
  • Product Name
    LMP2 Antibody, HRP conjugated
  • Delivery Days Customer
    20
  • Applications
    ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    HRP
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.
  • Reactivity
    Virus
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203