PDK1 Antibody

Cusabio

PDK1 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. Gudi R., J. Biol. Chem. 270:28989-28994(1995). Ota T., Nat. Genet. 36:40-45(2004). Burkard T.R., BMC Syst. Biol. 5:17-17(2011).

Human, Mouse, Rat

-20°C or -80°C

12352203