Phospho-BRCA1 (Ser1423) Antibody

Cusabio

Phospho-BRCA1 (Ser1423) Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation Kim ST, et al. (2002) Genes Dev; 16(5): 560-570 Arlt MF, et al. (2004) Mol Cell Biol; 24(15): 6701-6709 Zhang J, et al. (2004) Mol Cell Biol; 24(2): 708-718 Greenberg RA, et al. (2006) Genes Dev; 20(1): 34-46 Tibbetts RS, et al. (2000) Genes Dev; 14(23): 2989-3002

Human

-20°C or -80°C

12352203