Bio-Connect

Phospho-BRCA1 (Ser1457) Antibody

Research Use Only
CSB-PA258596
Cusabio
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Cusabio
  • Product Name
    Phospho-BRCA1 (Ser1457) Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation Miki Y., Science 266:66-71(1994). Smith T.M., Genome Res. 6:1029-1049(1996). Wilson C.A., Oncogene 14:1-16(1997).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203