Phospho-CAD (Thr456) Antibody

Cusabio

Phospho-CAD (Thr456) Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Iwahana H., Biochem. Biophys. Res. Commun. 219:249-255(1996). Davidson J.N., DNA Cell Biol. 9:667-676(1990). Olsen J.V., Cell 127:635-648(2006).

Human, Mouse

-20°C or -80°C

12352203