Phospho-FANCD2 (Ser222) Antibody

Cusabio

Phospho-FANCD2 (Ser222) Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. Ho GP, Margossian S, Taniguchi T, DAndrea AD (2006)Mol Cell Biol 26, 7005-15. Nakanishi K, et al. (2002)Nat Cell Biol 4, 913-20. Taniguchi T, et al. (2002) Cell 109, 459-72 .

Human, Mouse, Rat

-20°C or -80°C

12352203