Phospho-MAPT (Ser422) Antibody
CSB-PA277096
Overview
- SupplierCusabio
- Product NamePhospho-MAPT (Ser422) Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- HostRabbit
- IsotypeIgG
- Scientific DescriptionPromotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Gong CX, et al. (2006) J Biomed Biotechnol. 2006: 31825 Gamblin TC, et al. (2003) Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17): 10032-10037 Xu X., et al. (1997) Proc Natl Acad Sci U S A. Nov 11; 94(23): 12655-12660
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C
- UNSPSC12352203