Phospho-NTRK1 (Tyr757) Antibody

Cusabio

Phospho-NTRK1 (Tyr757) Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989). Shelton D.L., J. Neurosci. 15:477-491(1995). The MGC Project Team, Genome Res. 14:2121-2127(2004).

Human, Mouse

-20°C or -80°C

12352203