Phospho-TNK2 (Tyr284) Antibody

Cusabio

Phospho-TNK2 (Tyr284) Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Manser E., Nature 363:364-367(1993). Ota T., Nat. Genet. 36:40-45(2004). Eisenmann K.M., Nat. Cell Biol. 1:507-513(1999)

Human, Mouse

-20°C or -80°C

12352203