Rabbit anti-human DHCR7 polyclonal antibody

Immunohistochemistry of paraffin-em...

Product specifications for - Rabbit anti-human DHCR7 polyclonal antibody

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	ELISA, ImmunoHistoChemistry
Application note:	ELISA: 1:1000-1:2000, IHC: 1:25-1:100
Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG

Properties:
Purity:	Antigen affinity purification
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Form supplied:	Liquid
Storage instructions:	Shipped at 4-¦C. Upon delivery aliquot and store at -20-¦C or -80-¦C. Avoid repeated freeze.

Scientific information:
Scientific info:	This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS), a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.
Swiss prot ID:	Q9UBM7

Scientific information:

Scientific info:

This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS), a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

Swiss prot ID:

Q9UBM7

Additional information:
Synonyms:	CSB-PA110763

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Product specifications for - Rabbit anti-human DHCR7 polyclonal antibody