RNF20 Antibody, HRP conjugated
CSB-PA736198LB01HU
Overview
- SupplierCusabio
- Product NameRNF20 Antibody, HRP conjugated
- Delivery Days Customer20
- ApplicationsELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateHRP
- HostRabbit
- IsotypeIgG
- Scientific DescriptionComponent of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of \\\Lys-120\\\ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 \\\Lys-4\\\ and \\\Lys-79\\\ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203