RRP8 Antibody

Cusabio

RRP8 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. Yazaki M., Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases. Ishikawa K., DNA Res. 4:307-313(1997). The MGC Project Team; Genome Res. 14:2121-2127(2004).

Human

-20°C or -80°C

12352203