USP5 Antibody, FITC conjugated

Cusabio

USP5 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

Rabbit

IgG

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored \Lys-48\-linked polyubiquitin disassembly. Binds linear and \Lys-63\-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Human

-20°C or -80°C

12352203