Gd-IgA1 (Galactose-deficient IgA1) Assay Kit

Catalog number: 27600-96Well
Brand: IBL Japan
Packing: 96well
Price: On Request

Product specifications for - Gd-IgA1 (Galactose-deficient IgA1) Assay Kit

Product group: Assays
Category: ELISA / EIA
Species: Human
Conjugation: HRP
Assay Sample Type: Serum, EDTA-plasma
Assay Detection Range: 1.56 ~ 100 ng/mL
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116158
Form supplied: 1kit
Scientific information: 
Scientific info: Galactose-deficient IgA1 (Gd-IgA1) attracts a lot of attentions as a critical effector molecule in the pathogenesis and progression of IgA nephropathy (IgAN) in recent studies. It has been suggested that several O-link glycans modified regions exist in the heavy chain hinge region of human IgA1 molecule andGd-IgA1 circulates in blood stream of the patients with the pathological condition of IgAN. The measuring system using snail (helix aspersa, HAA) lectin that is extracted from snail has been used in past numerous studies and it was revealed that serum levels of Gd-IgA1 in patients with IgAN is significantly elevated compared with the level of healthy subjects or patients with renal diseases other than IgAN. Thus, the importance and purpose of measuring serum Gd-IgA1 level have been gradually recognized from such studies. However, since the measuring system used HAA lectin is not suitable for measuring multiple and massive samples in large scale studies due to its instability of glycan-recognizing activity, development of alternative measuring system that can quantitatively measure human Gd-IgA1 in serum with stable and reliable data has been considered as an essential and urgent matter. This IBL ELISA kit using the monoclonal antibody that specifically recognizes galactose-deficient hinge sequence of human Gd-IgA1 is a lectin non-dependent measuring system that can quantitatively measure Gd-IgA1 in human serum,which is also suitable for large scale studies because of its stability.
Additional information: 
Synonyms: 27600; IBL Japan; Gd-IgA1 (Galactose-deficient IgA1) Human ELISA
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Neufeld M, Molyneux K, Pappelbaum KI, et al. Galactose-deficient IgA1 in skin and serum from patients with skin-limited and systemic IgA vasculitis. J Am Acad Dermatol. 2019;81(5):1078-1085. Read more
Bagchi S, Lingaiah R, Mani K, et al. Significance of serum galactose deficient IgA1 as a potential biomarker for IgA nephropathy: A case control study. PLoS ONE. 2019;14(3):e0214256. Read more
Suzuki H, Yasutake J, Makita Y, et al. IgA nephropathy and IgA vasculitis with nephritis have a shared feature involving galactose-deficient IgA1-oriented pathogenesis. Kidney Int. 2018;93(3):700-705. Read more
Yamasaki K, Suzuki H, Yasutake J, Yamazaki Y, Suzuki Y. Galactose-Deficient IgA1-Specific Antibody Recognizes GalNAc-Modified Unique Epitope on Hinge Region of IgA1. Monoclon Antib Immunodiagn Immunother. 2018;37(6):252-256. Read more
Wada Y, Matsumoto K, Suzuki T, et al. Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy. PLoS ONE. 2018;13(11):e0206865. Read more
Yasutake J, Suzuki Y, Suzuki H, et al. Novel lectin-independent approach to detect galactose-deficient IgA1 in IgA nephropathy. Nephrol Dial Transplant. 2015;30(8):1315-21. Read more