Human Amyloidbeta (1-43) (FL)... | 27710-96Well | IBL Japan

Product specifications for - Human Amyloidbeta (1-43) (FL) Assay Kit

Overview:
Product group:	Assays
Category:	ELISA / EIA

Properties:
Assay Sample Type:	CSF, Cell culture supernatant
Assay Detection Range:	2.34 ~ 150 pg/mL
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	41116158
Form supplied:	1kit

Scientific information:
Scientific info:	The first case of Alzheimer's disease (AD) was defined and reported in 1907 by the German scientist, Dr. A. Alzheimer. His studies have shown that this is the main cause of dementia in the elderly. The plaques which appear in the brains of individuals who suffer AD are mostly constituted by the Amyloidbeta protein (Abeta). Abeta is a peptide which consists of 40 or 42 (43) amino acids, and reports show that this is cleaved from beta- and gamma- secretase from the amyloid precursor protein. APP is a trans-membrane protein consisting of 695, 751, or 770 amino acids. Reports have shown many variants of Abeta exist and are clarified into the culture supernatant from the APP cDNA transfected mouse neuroblastoma cell. Many types of Abeta molecules are targeted in AD research. A process, Abeta40 is produced by cleaving from Abeta49 through Abeta46 and Abeta43, has been reported in tripeptide hypothesis, partly for that reason the interest in Abeta43 molecules has been growing. This kit can measure full-length (FL) molecules of Human Abeta (1-43).

Scientific information:

Scientific info:

The first case of Alzheimer's disease (AD) was defined and reported in 1907 by the German scientist, Dr. A. Alzheimer. His studies have shown that this is the main cause of dementia in the elderly. The plaques which appear in the brains of individuals who suffer AD are mostly constituted by the Amyloidbeta protein (Abeta). Abeta is a peptide which consists of 40 or 42 (43) amino acids, and reports show that this is cleaved from beta- and gamma- secretase from the amyloid precursor protein. APP is a trans-membrane protein consisting of 695, 751, or 770 amino acids. Reports have shown many variants of Abeta exist and are clarified into the culture supernatant from the APP cDNA transfected mouse neuroblastoma cell. Many types of Abeta molecules are targeted in AD research. A process, Abeta40 is produced by cleaving from Abeta49 through Abeta46 and Abeta43, has been reported in tripeptide hypothesis, partly for that reason the interest in Abeta43 molecules has been growing. This kit can measure full-length (FL) molecules of Human Abeta (1-43).

Additional information:
Synonyms:	27710; IBL Japan; Amyloid Beta Aβ 1-43 Full Length Human ELISA; Alzheimer's Disease / Amyloid beta / Amyloid-beta / Amyloid Beta / Abeta / Beta Amyloid

Yoshida H, Meng P, Matsumiya T, et al. Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells. Neurosci Res. 2014;79:83-93.

Moriya M, Miyajima M, Nakajima M, Ogino I, Arai H. Impact of cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus on the amyloid cascade. PLoS ONE. 2015;10(3):e0119973.

Zou K, Liu J, Watanabe A, et al. Aβ43 is the earliest-depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE. Am J Pathol. 2013;182(6):2322-31.

Kakuda N, Shoji M, Arai H, et al. Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease. EMBO Mol Med. 2012;4(4):344-52.

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Human Amyloidbeta (1-43) (FL) Assay Kit

Product specifications for - Human Amyloidbeta (1-43) (FL) Assay Kit

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Human Amyloidbeta (1-43) (FL) Assay Kit

Product specifications for - Human Amyloidbeta (1-43) (FL) Assay Kit