Catalog number: BI-20413
Brand: Biomedica
Packing: 96 tests
Price: On Request
Expected delivery time: 7 days

Product specifications for - Human DKK-1 ELISA

Product group: Assays
Category: ELISA / EIA
Application note: ELISA
Species: Human
Reactivity note: human
Molecular weight: 25.8 kDa
Assay Sensitivity: 1.7 pmol/l (= 43.0 pg/ml)
Assay Specificity: Dickkopf-1, DKK-1
Assay Precision: intra-assay: 3%, inter-assay: 3%
Assay Sample Type: Serum
Assay Time: 2 h / 1 h / 30 min
Assay Detection Range: 10-160 pmol/l
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116133
Scientific information: 
Scientific info: Product Characteristics: The Biomedica human DKK-1 (Dickkopf-1) Sandwich ELISA (enzyme-linked immunosorbent assay) kit is a quick day test that is intended for the quantitative direct measurement of DKK-1 levels in human serum samples. The human DKK-1 ELISA is highly recognised with +130 references to date, CE certified and approved for in-vitro diagnostic use in the EU.Target information: Dickkopf-1 (DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the Wnt signalling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity, and gene expression. DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumourgenetic activity.
Gene ID: 22943
Swiss prot ID: O94907
Safety information: 
Additional information: 
Synonyms: BI-20413; Biomedica Gruppe; Dickkopf 1; dickkopf WNT signaling pathway inhibitor; Dickkopf-1; dkk 1; dkk1; WNT
Klotz DM et al., „ Evaluation of circulating Dickkopf-1 as a prognostic biomarker in ovarian cancer patients.” Clin Chem Lab Med. (2021) 25;60(1):109-117. Read more
Fassio A et al., “Pharmacodynamics of Oral Cholecalciferol in Healthy Individuals with Vitamin D Deficiency: A Randomized Open-Label Study.” Nutrients. (2021) 13(7):2293. Read more
Klingenschmid G et al., “Associations of Serum Dickkopf-1 and Sclerostin With Cardiovascular Events: Results From the Prospective Bruneck Study.” J Am Heart Assoc. (2020) 17;9(6):e014816. Read more
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