Human N-ERC/Mesothelin Assay Kit

Catalog number: 27190-96Well
Brand: IBL Japan
Packing: 96well
Price: On Request
Expected delivery time: 10 days

Product specifications for - Human N-ERC/Mesothelin Assay Kit

Product group: Assays
Category: ELISA / EIA
Species: Human
Conjugation: HRP
Assay Sample Type: EDTA-plasma
Assay Detection Range: 0.07 ~ 4.4 ng/mL
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116158
Form supplied: 1kit
Scientific information: 
Scientific info: Erc has been identified as a gene showing stronger expression in cancer-affected renal tissue than in normal renal tissue in Eker rats (a rat model of renal cancer). The human homologue of the protein encoded by this gene is called MPF (megakaryocyte potentiating factor) or mesothelin. This protein is detected especially prominently in mesothelial cells, and its involvement has been suggested in the development of mesothelioma, making it a promising tumor marker. In humans, involvement of this protein has also been suggested in the development of pancreatic, ovarian and pulmonary cancers, etc. The protein is expressed as a GPI anchor-type membranous protein (about 71 kDa in molecular weight), which is digested by a furin-like protease to yield fragments about 31 kDa and 40 kDa in size. We have established a system for the assay of this protein, referring to the 31 kDa fragment as N-ERC/Mesothelin. This ELISA kit can measure N-ERC/Mesothelin in human plasma samples.
Additional information: 
Synonyms: 27190; IBL Japan; N-ERC/Mesothelin Human ELISA
Sato T, Suzuki Y, Mori T, et al. Newly established ELISA for N-ERC/mesothelin improves diagnostic accuracy in patients with suspected pleural mesothelioma. Cancer Med. 2014;3(5):1377-84. Read more
Creaney J, Sneddon S, Dick IM, et al. Comparison of the diagnostic accuracy of the MSLN gene products, mesothelin and megakaryocyte potentiating factor, as biomarkers for mesothelioma in pleural effusions and serum. Dis Markers. 2013;35(2):119-27. Read more