Human sAPPalpha (highly sensitive) Assay Kit

Catalog number: 27734-96Well
Brand: IBL Japan
Packing: 96well
Other sizes: Other sizes available
Price: On Request
Expected delivery time: 10 days

Product specifications for - Human sAPPalpha (highly sensitive) Assay Kit

Product group: Assays
Category: ELISA / EIA
Species: Human
Conjugation: HRP
Assay Sample Type: EDTA-plasma, Serum, CSF, Cell culture supernatant
Assay Detection Range: 0.78 ~ 50 ng/mL
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116158
Form supplied: 1kit
Scientific information: 
Scientific info: Alzheimer's disease (AD) was first reported by A. Alzheimer, a German neuropathologist in 1907 and is considered as a major factor of dementia. It is known that Amyloid beta (Abeta, which is major constituent of senile plaque) is cleaved from Amyloid Precursor Protein (APP, which exists in three main isoforms, APP695, APP751, and APP770) by beta-secretase and subsequent gamma-secretase. The production of soluble APPbeta (sAPPbeta) by beta-secretase cleavage corresponds to Abeta production accordingly, so it is desired to measure sAPPbeta in parallel with Abeta. In addition, it is reported that APP gene mutation exists in individuals who suffer early-onset Alzheimer s disease. Swedish mutation, one of the APP gene mutations, is a double mutation at positions -1 to -2 from the beta-secretase cleavage site (Lys670 to Asn and Met671 to Leu) . And further, it is reported that Swedish mutation elevates Abeta40 and Abeta42 production, and that the mutation is utilized in establishment of transgenic mice. The measuring sAPPbeta in Swedish type is useful for research of AD as well as in wild type. On the one hand, it is considered that in the metabolic pathway of APP, APP is first cleaved by alpha-secretase rather than beta-secretase normally to produce soluble APPalpha (sAPPalpha) and subsequently P3 is cleaved from the remaining C-terminal fragment by gamma-secretase. This kit can measure human sAPPalpha in samples . IBL has many other kinds of Amyloidbeta-related products for AD research. They are very specific assay systems for each target and they can be used according to the purpose of study. The control set is available for sale on request.
Additional information: 
Synonyms: 27734; IBL Japan; sAPP Alpha α (highly sensitive) Human ELISA
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