Human soluble alpha-Klotho Assay Kit

Catalog number: 27998-96Well
Brand: IBL Japan
Packing: 96well
Other sizes: Other sizes available
Price: On Request
Expected delivery time: 10 days

Product specifications for - Human soluble alpha-Klotho Assay Kit

Product group: Assays
Category: ELISA / EIA
Assay Sample Type: Plasma, Serum, Cell culture supernatant, Urine
Assay Detection Range: 93.75 ~ 6,000 pg/mL
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116158
Form supplied: 1kit
Scientific information: 
Scientific info: alpha-Klotho (Alpha Klotho) was identified as an extremely down-regulated gene in the genetically-modified mouse of which phenotype is very similar to various symptoms of human aging. The sequences of Alpha Klotho genes have been identified in various species including humans based on the one of mouse. Alpha Klotho protein is a 130 kDa, one-transmembrane protein and its expression is confirmed in the kidneys and the parathyroid glands. In recent years, it has become clear that Alpha Klotho is an important molecule within a living organism regulating the metabolism of mineral such as calcium and phosphorus. It is considered that in Alpha Klotho mouse, early aging-like symptoms are induced by impaired mineral homeostasis caused by decreased expression of Alpha Klotho. Meanwhile, it is reported that the long N-terminal extracellular domain which comprises the major portion of sequence of Alpha Klotho protein is released free into blood by shedding. However, there are many unclear points about functions and changes in concentration of free (soluble) Alpha Klotho protein, so it was required to develop the measurement system of Alpha Klotho. This ELISA kit can measure Human soluble Alpha Klotho protein in human blood. The control set is available for sale on request.
Additional information: 
Synonyms: 27998; IBL Japan; Alpha α Klotho soluble Human ELISA; alpha-Klotho / Alpha Klotho / FGF23 / Kidney disease / Chronic Kidoeny disease (CKD) / Mineral Bone Disease (MBD) / Osteoporosis / Aging
Morishima T, Ochi E. Impact of a single bout of resistance exercise on serum Klotho in healthy young men. Physiol Rep. 2021;9(21):e15087. Read more
Taneike M, Nishida M, Nakanishi K, et al. Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure. Sci Rep. 2021;11(1):2058. Read more
Shardell M, Drew DA, Semba RD, et al. Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults. J Endocr Soc. 2020;4(5):bvz032. Read more
Martín-núñez E, Donate-correa J, Ferri C, et al. Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: a case-control study. Aging (Albany NY). 2020;12(2):1952-1964. Read more
Bergmark BA, Udell JA, Morrow DA, et al. Klotho, fibroblast growth factor-23, and the renin-angiotensin system - an analysis from the PEACE trial. Eur J Heart Fail. 2019;21(4):462-470. Read more
Woo HG, Chang Y, Ryu DR, Song TJ. Plasma Klotho concentration is associated with the presence, burden and progression of cerebral small vessel disease in patients with acute ischaemic stroke. PLoS ONE. 2019;14(8):e0220796. Read more
Buendia-roldan I, Machuca N, Mejía M, Maldonado M, Pardo A, Selman M. Lower levels of α-Klotho in serum are associated with decreased lung function in individuals with interstitial lung abnormalities. Sci Rep. 2019;9(1):10801. Read more
Picciotto D, Murugavel A, Ansaldo F, et al. The Organ Handling of Soluble Klotho in Humans. Kidney Blood Press Res. 2019;44(4):715-726. Read more
Nakanishi K, Nishida M, Taneike M, et al. Implication of alpha-Klotho as the predictive factor of stress. J Investig Med. 2019;67(7):1082-1086. Read more
Shardell M, Semba RD, Kalyani RR, et al. Plasma Klotho and Frailty in Older Adults: Findings From the InCHIANTI Study. J Gerontol A Biol Sci Med Sci. 2019;74(7):1052-1057. Read more