Mouse soluble alpha-Klotho Assay Kit

Catalog number: 27601-96Well
Brand: IBL Japan
Packing: 96well
Price: On Request
Expected delivery time: 10 days

Product specifications for - Mouse soluble alpha-Klotho Assay Kit

Product group: Assays
Category: ELISA / EIA
Species: Mouse
Conjugation: HRP
Assay Sample Type: Urine
Assay Detection Range: 78.13 ~ 5000 pg/mL
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116158
Form supplied: 1kit
Scientific information: 
Scientific info: alpha-klotho (Alpha Klotho) was identified as an extremely down-regulated gene in the genetically-modified mouse of which phenotype is very similar to various symptoms of human aging. Then, the sequences of Alpha Klotho genes have been identified in various species including humans based on the one of mouse. Alpha Klotho protein is a 130 kDa, one-transmembrane protein and its expression is confirmed in the kidneys and the parathyroid glands. In recent years, it has become clear that Alpha Klotho is an important molecule within a living organism regulating the metabolism of mineral such as calcium and phosphorus. Therefore, it is considered that, in Alpha Klotho mouse, early aging-like symptoms are induced by impaired mineral homeostasis caused by decreased expression of Alpha Klotho. Meanwhile, it is reported that the long N-terminal extracellular domain which comprises the major portion of sequence of Alpha Klotho protein is released free into blood by shedding. However, there are many unclear points about functions and changes in concentration of free (soluble) Alpha Klotho protein, so it has been required to develop the measurement system of Alpha Klotho. This ELISA kit can measure mouse soluble Alpha Klotho protein in mouse urine. The control set is available for sale on request.
Additional information: 
Synonyms: 27601; IBL Japan; Alpha α Klotho soluble Mouse ELISA; alpha-Klotho / Alpha Klotho / FGF23 / Kidney disease / Chronic Kidoeny disease (CKD) / Mineral Bone Disease (MBD) / Osteoporosis / Aging