Titin N-Fragment Assay Kit

Catalog number: 27900-96Well
Brand: IBL Japan
Packing: 96well
Price: € 754.00
Expected delivery time: 10 days
Quantity:

Product specifications for - Titin N-Fragment Assay Kit

Overview: 
Product group: Assays
Category: ELISA / EIA
Species: Human, Rat
Conjugation: HRP
Properties: 
Assay Sample Type: Urine
Assay Detection Range: 46.88 ~ 3000 pmol/L
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116158
Form supplied: 1kit
Scientific information: 
Scientific info: Titin (connectin) is a protein that consists of 34,350 amino-acid and specifically expresses in a cross-striated muscle. The molecular weight of human titin is 3,816 kDa and it has been known that as the largest protein among of existing proteins in a living body. It is one of sarcomere structured protein that is a minimum unit of myofibrillary protein and it has a role as an elastic protein for recovering the length of shortened sarcomere by its contraction. It has been known that titin is cleaved by protein metabolic enzymes such as calpain and matrix metalloprotease if muscles are damaged. In fact, it has been confirmed that titin is dramatically cleaved in skeletal muscles of muscular dystrophy patients and various titin fragments are confirmed in blood and urine. It has been reported that the N fragment (26kDa) and the C fragment (12kDa) are especially increased in urine of muscular dystrophy patients and it is also suggested that it can be a candidate as a non-invasiveness biomarker for monitoring status of muscles. This ELISA kit can measure titin N fragment in human and rat urine. The control set is available for sale on request.
Additional information: 
Synonyms: 27900; IBL Japan; Titin N-Fragment Human, Rat ELISA
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Fukushima S, Nakanishi N, Fujioka K, et al. Assessment of catabolic state in infants with the use of urinary titin N-fragment. Pediatr Res. Published online July 17, 2021. Read more
Nakano H, Hashimoto H, Mochizuki M, et al. Urinary titin n-fragment evaluation in a randomized controlled trial of beta-hydroxy-beta-methylbutyrate for acute mild trauma in older adults. Nutrients. 2021;13(3):899. Read more
Yamada S, Hashizume A, Hijikata Y, et al. Ratio of urinary N-terminal titin fragment to urinary creatinine is a novel biomarker for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2021;92(10):1072-1079. Read more
Tanabe Y, Shimizu K, Sagayama H, Fujii N, Takahashi H. Urinary N-terminal fragment of titin: A surrogate marker of serum creatine kinase activity after exercise-induced severe muscle damage. J Sports Sci. 2021;39(13):1437-1444. Read more
Nakanishi N, Tsutsumi R, Hara K, Matsuo M, Sakaue H, Oto J. Urinary titin n-fragment as a biomarker of muscle atrophy, intensive care unit-acquired weakness, and possible application for post-intensive care syndrome. J Clin Med. 2021;10(4):614. Read more
Tanabe Y, Shimizu K, Kondo E, et al. Urinary n-terminal fragment of titin reflects muscle damage after a soccer match in male collegiate soccer players. J Strength Cond Res. 2021;35(2):360-365. Read more
Sato T, Awano H, Ishiguro K, et al. Urinary titin as a biomarker in Fukuyama congenital muscular dystrophy. Neuromuscul Disord. 2021;31(3):194-197. Read more
Ishihara M, Nakanishi N, Tsutsumi R, et al. Elevated urinary titin and its associated clinical outcomes after acute stroke. J Stroke Cerebrovasc Dis. 2021;30(3):105561. Read more
Nakano H, Matsubara T, Yamakawa K, Nakamura K. Urine TITIN N-fragment as a novel biomarker for critical illness myopathy: a pilot study. Crit Care. 2020;24(1):177. Read more