Big ET - independent predictor of long-term mortality in patients with three-vessel disease

Endothelin-1 (ET-1) is a potent vasoconstrictor secreted by vascular endothelial cells. Due to its high biologic activity, ET-1 is rapidly cleared. However, big ET-1, the precursor of ET-1, has a much longer half-life, circulates in higher concentrations and is easier to detect. Thus, big-ET-1 is a more suitable marker and can be used as an alternative approach for the indirect estimation of ET-1 release. Big ET-1 has been implicated in the pathophysiology of numerous cardiovascular diseases.

Big ET can easily be measured using Biomedica's Big Endothelin-1 ELISA.