BMP-2 Protein, Human/Mouse/Rat

MedChem Express

BMP-2 Protein, Human/Mouse/Rat

10

Bone morphogenetic protein 2

Bone morphogenetic protein 2 (BMP-2) is a pleiotropic ligand protein belonging to TNFbeta family, and is involved in key embryonic development of vascular and valvular homeostasis. BMP-2 binds to type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A) to regulate various types of calcification, including atherosclerosis, chronic kidney disease, diabetes, and valve calcification. BMP-2 is overexpressed by myofibroblast and preosteoblast in the calcified area of human calcified valve, which are densely infiltrated by B lymphocytes and T lymphocytes. BMP-2 is the junction between atherosclerotic vascular calcification and normal bone formation mechanism. BMP-2 Protein, Human/Mouse/Rat is 104 a.a. (Q283-R396), expressed in E. coli.

2°C to 8°C,-20°C or -80°C

12352202