Recombinant Human Transmembrane protease serine 2(TMPRSS2),partial

Catalog number: CSB-YP023924HU_100ug
Brand: Cusabio
Packing: 100 ug
Other sizes: Other sizes available, please contact us.
Price: On Request
Expected delivery time: 14 days
Quantity:

Product specifications for - Recombinant Human Transmembrane protease serine 2(TMPRSS2),partial

Overview: 
Product group: Corona Related Products
Category: Proteins
Subcategory: Recombinant protein
Host: Yeast
Source: Homo sapiens (Human)
Properties: 
Purity: Greater than 90% as determined by SDS-PAGE.
Molecular weight: 44,8 kDa
Datasheet: Datasheet
UNSPSC: 12352202
Storage instructions: Repeated freezing and thawing is not recommended. Store working aliquots at 4-¦C for up to one week.
Scientific information: 
Scientific info: Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions, spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9), involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
Swiss prot ID: O15393