FGFR4-IN-8
HY-145836
Molecular Weight654.56
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameFGFR4-IN-8
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC32H34Cl2FN7O3
- Molecular Weight654.56
- Scientific DescriptionFGFR4-IN-8 (Compound 7v) is an ATP-competitive, highly selective covalent inhibitor of wild-type and gatekeeper mutant FGFR4. FGFR4-IN-8 exhibits excellent potency against FGFR4, FGFR4V550L, FGFR4V550M and FGFR4C552S with IC50s of 0.5, 0.25, 1.6, 931 nM, respectively. FGFR4-IN-8 exhibits potent antiproliferative activity against Hep3B hepatocellular carcinoma cells with the IC50 value of 29 nM. FGFR4-IN-8 demonstrates modest in vivo antitumor efficacy in nude mice bearing the Huh-7 xenograft model.
- SMILESC[C@@H](OC1=CC=C(C2=C1)NN=C2NC3=C(C=C(C=C3F)N4CCC(CC4)N5CCOCC5)NC(C=C)=O)C6=C(C=NC=C6Cl)Cl
- Storage InstructionSee Manual
- UNSPSC12352200