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Products for Research on Factor VIII
Active Interleukin 10 (IL10)
Catalog number:
APA056HU61_50ug
Brand:
Cloud-Clone Corp.
Packing:
50 ug
Price:
On Request
Expected delivery time:
7 days
Quantity:
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General
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Interleukin 10 (IL-10), also known ...
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 was initially reported to suppress cytokine secretion, antigen presentation and CD4 T cell activation. Further investigation has shown that IL-10 predominantly inhibits lipopolysaccharide (LPS) mediated induction of the pro-inflammatory cytokines TNFα, IL-1β, IL-12, and IFNγ made by cells such as macrophages and Th1 T cells. Therefore, THP1 cells were cultured in 24 well plates at a concentration of 106 cells/ml and activated by LPS (1ug/mL) in the absence or presence of IL-10 (5ng/mL, 10ng/mL) for 24h and production of IL-1β was determined in the supernatants by cytokine specific ELISA.
Activation of THP1 cells with LPS (1ug/mL) resulted in high levels of production of IL-1β and strong inhibitory effects of IL-10 (5ng/mL, 10ng/mL) were observed on the production of IL-1β as shown in Table 1.
Product specifications for - Active Interleukin 10 (IL10)
Overview:
Product group:
Corona Related Products
Category:
Chemokines / cytokines
Application:
Other Application
Application note:
Cell culture, Activity Assays, In vivo assays.
Modification:
N-terminal His Tag
Properties:
Purity:
> 97%
Molecular weight:
18kDa
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352202
Scientific information:
Scientific info:
Eukaryotic expression
Swiss prot ID:
P22301
Additional information:
Synonyms:
APA056HU61