Recombinant Human DNASE1 / Deoxyribonuclease I / DNL1 Protein (His tag)

Catalog number: PKSH030557_20ug
Brand: Elabscience
Packing: 20 ug
Other sizes: Other sizes available, please contact us.
Price: € 423.00
Expected delivery time: 14 days

Product specifications for - Recombinant Human DNASE1 / Deoxyribonuclease I / DNL1 Protein (His tag)

Product group: Proteins / Signaling Molecule
Category: Proteins
Subcategory: Recombinant protein
Source: Human
Purity: >85 % as determined by SDS-PAGE
  Research Use Only
UNSPSC: 12352202
Form supplied: Lyophilized from sterile PBS, pH 7.4
Storage instructions: Samples are stable for up to twelve months from date of receipt at -70-¦C. Store it under sterile conditions at -20-¦C to -80-¦C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Scientific information: 
Scientific info: DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations in DNase1 gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. DNase1 is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity.
Swiss prot ID: P24855