Research Use Only Assays from Invivoscribe



Next-Generation Sequencing Assays

B Cell Gene Rearrangement

LymphoTrack® IGH Assay - MiSeq
Identifies clonal IGH V-J rearrangements, the associated V-J region DNA sequences, and provides the frequency distribution of V region and J region segment utilization using the Illumina MiSeq® platform. 

LymphoTrack® IGH Assay - PGM
Identifies clonal IGH V-J rearrangements, the associated V-J region DNA sequences, and provides the frequency distribution of V region and J region segment utilization using the Ion PGM™ platform.

T Cell Gene Rearrangement

LymphoTrack® TCRG Assay - MiSeq
Identifies clonal TCRG V-J rearrangements, the associated V-J region DNA sequences, and provides the frequency distribution of V region and J region segment utilization using the Illumina MiSeq® platform.

LymphoTrack® TCRG Assay - PGM
Identifies clonal TCRG V-J rearrangements, the associated V-J region DNA sequences, and provides the frequency distribution of V region and J region segment utilization using the Ion PGM™ platform.



Mutation and Translocation Assays

BCL1/JH Translocation Assays
Developed by the BIOMED-2 Group, these assays identify BCL1/JH t(11;14) translocations using a single master mix that targets BCL1 MTC locus of chromosome 11 and the JH locus of chromosome 14.

BCL2/JH t(14;18) Translocation Assays
Identifies BCL2/JH t(14;18) translocations using four master mixes that target the Mbr and mcr loci on chromosome 18 and the JH locus of chromosome 14. This assay can be performed as a nested or non-nested assay.

BCL2/JH Translocation Assays
Developed by the BIOMED-2 Group, these assays identify BCL2/JH t(14;18) translocations using three master mixes that target the Mbr, 3' Mbr, and mcr loci on chromosome 18, and the JH locus of chromosome 14.

BCR/ABL t(9;22) Translocation Assays
Identifies BCR/ABL t(9;22) translocations using seven master mixes that target the p190 e1a2, p210 b3a2, and p210 b2a2 translocation products. This assay is a nested assay.

PML/RARa t(15;17) Translocation Assays
Identifies PML/RARa t(15;17) translocations using three master mixes that target both the short and long form translocation products. This assay is a nested assay.



Clonality Assays

B Cell Gene Rearrangement

IGH Somatic Hypermutation
Used to test chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) specimens.

IGH Gene Rearrangement Assays
Identifies IGH gene rearrangements using three master mixes that target the Framework 1-3 regions.

IGH Gene Clonality Assays
Developed by the BIOMED-2 Group, these assays identify IGH gene rearrangements using three master mixes that target the Framework 1-3 regions, and two master mixes that target the DH-JH rearrangements.

IGK Gene Clonality Assays
Developed by the BIOMED-2 Group, these assays identify IGK gene rearrangements using two master mixes that target the Vk 1-7 segments, the Kappa deletion element, and intron segment.

IGL Gene Clonality Assays
Developed by the BIOMED-2 Group, these assays identify gene rearrangements using a single master mix that targets the Vl 1-3 segments.

T Cell Gene Rearrangement

TCRB Gene Clonality Assays
Developed by the BIOMED-2 Group, these assays identify gene rearrangements using three master mixes that target the Vb 1-24 and Db 1&2 gene segments.

TCRD Gene Clonality Assays
Developed by the BIOMED-2 Group, these assays identify gene rearrangements using a single master mix that targets the Vd 1-6 and Dd 2&3 gene segments.

TCRG Gene Rearrangement Assay 2.0
New multiplex PCR assay can detect the vast majority of TCRG gene rearrangements with a single multiplex master mix.

TCRG Gene Rearrangement Assay
Identifies gene rearrangements with two master mixes that target the Vg gene segments.

TCRG Gene Clonality Assay
Developed by the BIOMED-2 Group, these assays identify gene rearrangements using two master mixes that target the Vg gene segments.



Master Mixes

Template Amplification Controls
Template amplification control master mixes are designed to test the quality and quantity of the DNA or RNA to be used in an assay.

B Cell Gene Rearrangement/Clonality Master Mixes

IGH Gene Rearrangement/Clonality Master Mixes
All IGH master mixes contained in both the IGH Gene Rearrangement Assays and the IGH Gene Clonality Assays.

IGK Gene Clonality Master Mixes
All IGK master mixes contained in the IGK Gene Clonality Assays.

IGL Gene Clonality Master Mixes
All IGL master mixes contained in the IGL Gene Clonality Assays.

T Cell Gene Rearrangement/Clonality Master Mixes

TCRB Gene Clonality Master Mixes
All TCRB master mixes contained in the TCRB Gene Clonality Assays.

TCRD Gene Clonality Master Mixes
All TCRD master mixes contained in the TCRD Gene Clonality Assays.

TCRG Gene Rearrangement 2.0
New improved and comprehensive approach for rapid TCRG clonality assessment. The lone master mix targets all conserved regions within the variable (V) and joining (J) region genes allowing for a more sensitive and robust clonality detection assay.

TCRG Gene Rearrangement/Clonality Master Mixes
All TCRG master mixes contained in both the T Cell Receptor Gamma Gene Rearrangement Assays, and the TCRG Gene Clonality Assays.

Translocation Master Mixes

BCL1/JH t(11;14) Translocation Master Mixes
All BCL1 master mixes contained in the BCL1/JH Translocation Assays.

BCL2/JH t(14;18) Translocation and BCL2/JH Translocation Master Mixes
All BCL2 master mixes contained in both the BCL2/JH t(14;18) Translocation Assays, and BCL2/JH Translocation Assays.

BCR/ABL t(9;22) Translocation Master Mixes
All BCR/ABL master mixes contained in the BCR/ABL t(9;22) Translocation Assays.



Related to:
Brands: Invivoscribe
Product groups: Assays