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RO8994

T3517
TargetMol Chemicals
CAS Number1309684-94-3
Product group Chemicals
Molecular Weight613.51
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    RO8994
  • Delivery Days Customer
    4
  • CAS Number
    1309684-94-3
  • Category Supplier
    Chemical
  • Chemical Name
    RO8994
  • Molecular Formula
    C31H31Cl2FN4O4
  • Molecular Weight
    613.51
  • Scientific Description
    RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).
  • Shelf life instruction
    3 years
  • SMILES
    C(C(C)(C)C)[C@H]1[C@@]2([C@H]([C@H](C(NC3=C(OC)C=C(C(N)=O)C=C3)=O)N1)C4=C(F)C(Cl)=CC=C4)C=5C(NC2=O)=CC(Cl)=CC5
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Zhang Z,et al. Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg Med Chem. 2014 Aug 1;22(15):4001-9.