TNF-alfa-IN-2

TargetMol Chemicals

TNF-alfa-IN-2

107

2074702-04-6

Chemical

TNF-alfa-IN-2

C25H21ClF2N6O

494.92

TNF-alfa-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFalfa), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFalfa trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-alfa-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1].

3 years

N([C@H](C)C1=CC(C#N)=CC=C1F)C=2C3=C(C=C(F)C(=N3)C=4C=NC(C(C)(C)O)=NC4)N=C(C)C2Cl

-20°

12352200