TNF-alpha-IN-2 [2074702-04-6]
HY-134471
CAS Number2074702-04-6
Product group Chemicals
Estimated Purity98.12%
Molecular Weight494.92
Overview
- SupplierMedChem Express
- Product NameTNF-alpha-IN-2 [2074702-04-6]
- Delivery Days Customer10
- CAS Number2074702-04-6
- Estimated Purity98.12%
- Molecular FormulaC25H21ClF2N6O
- Molecular Weight494.92
- Scientific DescriptionTNF-alpha-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFalpha), with an IC50 of 25 nM in the HTRF assay. TNF-alpha-IN-2 distorts the TNFalpha trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-alpha-IN-2 can be used for the research of rheumatoid arthritis.
- SMILESC[C@H](C1=CC(C#N)=CC=C1F)NC2=C(C(C)=NC3=CC(F)=C(C4=CN=C(C(C)(O)C)N=C4)N=C23)Cl
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200